Low IgE Is a Useful Tool to Identify STAT3 Gain-of-Function Mutations

Clin Chem. 2016 Nov;62(11):1536-1538. doi: 10.1373/clinchem.2016.263624. Epub 2016 Sep 8.

Authors

Matthew B Johnson¹, Sarah E Flanagan¹, Thomas B Martins², Harry R Hill², Andrew T Hattersley¹, Timothy J McDonald^{3

4}

Affiliations

¹ Institute of Biomedical and Clinical Science University of Exeter Medical School, Exeter, Devon, UK.
² Department of Pathology the ARUP Institute for Clinical and Experimental Pathology University of Utah, Salt Lake City, UT.
³ Institute of Biomedical and Clinical Science University of Exeter Medical School, Exeter, Devon, UK [email protected].
⁴ Molecular Genetics and Blood Sciences Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases / genetics
Child
Child, Preschool
Gain of Function Mutation*
Genetic Testing / methods
Germ-Line Mutation
Humans
Immunoglobulin E / blood*
Infant
STAT3 Transcription Factor / genetics*
Sensitivity and Specificity

Substances

STAT3 Transcription Factor
STAT3 protein, human
Immunoglobulin E

Grants and funding