Potentiometric sensor fabrication having 2D sarcosine memories and analytical features

Mater Sci Eng C Mater Biol Appl. 2016 Dec 1:69:231-5. doi: 10.1016/j.msec.2016.06.057. Epub 2016 Jun 21.

Abstract

In this study, a simple, rapid and sensitive method based on novel molecular imprinted polymeric sensor has been developed and validated for the determination of prostate cancer metabolite biomarker. The molecularly imprinted polymer (MIP) has been synthesized by emulsion polymerization, using sarcosine as template molecule, methacryloylamido histidine (MAH) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linking agent. The performance of the developed sarcosine sensor has been evaluated, and the results have indicated that a sensitive potentiometric sensor has been fabricated. The sarcosine sensor has showed high-selectivity, shorter response time (<2min), wider linear range (10(-2)-10(-6)mM), lower detection limit (1.35×10(-7)mM), and satisfactory long-term stability (>5.5months).

Keywords: MIP; Potentiometric sensor; Prostate cancer; Sarcosine.

MeSH terms

  • Biomarkers, Tumor / analysis
  • Histidine / chemistry
  • Humans
  • Hydrogen-Ion Concentration
  • Limit of Detection
  • Molecular Imprinting*
  • Polymers / chemistry*
  • Potentiometry*
  • Reproducibility of Results
  • Sarcosine / analysis*
  • Sarcosine / chemistry
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Biomarkers, Tumor
  • Polymers
  • Histidine
  • Sarcosine