The Computational Properties of a Simplified Cortical Column Model

PLoS Comput Biol. 2016 Sep 12;12(9):e1005045. doi: 10.1371/journal.pcbi.1005045. eCollection 2016 Sep.

Abstract

The mammalian neocortex has a repetitious, laminar structure and performs functions integral to higher cognitive processes, including sensory perception, memory, and coordinated motor output. What computations does this circuitry subserve that link these unique structural elements to their function? Potjans and Diesmann (2014) parameterized a four-layer, two cell type (i.e. excitatory and inhibitory) model of a cortical column with homogeneous populations and cell type dependent connection probabilities. We implement a version of their model using a displacement integro-partial differential equation (DiPDE) population density model. This approach, exact in the limit of large homogeneous populations, provides a fast numerical method to solve equations describing the full probability density distribution of neuronal membrane potentials. It lends itself to quickly analyzing the mean response properties of population-scale firing rate dynamics. We use this strategy to examine the input-output relationship of the Potjans and Diesmann cortical column model to understand its computational properties. When inputs are constrained to jointly and equally target excitatory and inhibitory neurons, we find a large linear regime where the effect of a multi-layer input signal can be reduced to a linear combination of component signals. One of these, a simple subtractive operation, can act as an error signal passed between hierarchical processing stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Computational Biology
  • Computer Simulation
  • Mammals
  • Models, Neurological*
  • Neocortex / physiology*
  • Neurons / physiology*

Grants and funding

This work was funded by the Allen Institute for Brain Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.