A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop; Heather Thorne; Shahneen Sandhu; Anne Hamilton; Christopher Mintoff; Elizabeth Christie; Odette Spruyt; Scott Williams; Orla McNally; Linda Mileshkin; Sumitra Ananda; Julene Hallo; Sherene Loi; Clare Scott; Peter Savas; Lisa Devereux; Patricia O'Brien; Sameera Gunawardena; Clare Hampson; Kate Strachan; Rufaro Diana Jaravaza; Victoria Francis; Gregory Young; David Ranson; Ravindra Samaranayake; David Stevens; Samantha Boyle; Clare Fedele; Monique Topp; Gwo Ho; Zhi Ling Teo; Renea A Taylor; Melissa M Papargiris; Mitchell G Lawrence; Hong Wang; Gail P Risbridger; Nicole M Haynes; Mikolaj Medon; Ricky W Johnstone; Eva Vidacs; Gisela Mir Arnau; Ismael A Vergara; Anthony T Papenfuss; Grant McArthur; Paul Waring; Shirley Carvosso; Christopher Angel; David Gyorki; Benjamin Solomon; Gillian Mitchell; Sue Shanley; Prudence A Francis; Sarah-Jane Dawson; Amy Haffenden; Erin Tidball; Mila Volchek; Jan Pyman; Mohammed Madadin; Jodie Leditschke; Stephen Cordner; Melbourne Melanoma Project; Australian Ovarian Cancer Study Group (AOCS); Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Mark Shackleton; David D Bowtell

doi:10.1038/nbt.3674

A community-based model of rapid autopsy in end-stage cancer patients

Nat Biotechnol. 2016 Oct;34(10):1010-1014. doi: 10.1038/nbt.3674. Epub 2016 Sep 12.

Authors

Kathryn Alsop¹, Heather Thorne^{1

2}, Shahneen Sandhu³, Anne Hamilton^{3

4

5}, Christopher Mintoff⁶, Elizabeth Christie^{1

7}, Odette Spruyt^{5

8}, Scott Williams⁹, Orla McNally^{4

10}, Linda Mileshkin^{3

7}, Sumitra Ananda^{3

4}, Julene Hallo⁴, Sherene Loi^{3

7

11}, Clare Scott¹², Peter Savas^{3

11}, Lisa Devereux⁷, Patricia O'Brien¹³, Sameera Gunawardena¹³, Clare Hampson¹³, Kate Strachan¹³, Rufaro Diana Jaravaza¹³, Victoria Francis¹³, Gregory Young¹³, David Ranson¹³, Ravindra Samaranayake¹³, David Stevens¹⁴, Samantha Boyle⁶, Clare Fedele^{6

7

15}, Monique Topp¹², Gwo Ho¹², Zhi Ling Teo^{7

11}, Renea A Taylor¹⁶, Melissa M Papargiris¹⁷, Mitchell G Lawrence¹⁷, Hong Wang¹⁷, Gail P Risbridger¹⁷, Nicole M Haynes^{7

18}, Mikolaj Medon^{18

19}, Ricky W Johnstone^{7

18}, Eva Vidacs¹⁸, Gisela Mir Arnau²⁰, Ismael A Vergara^{12

21}, Anthony T Papenfuss^{7

18

21}, Grant McArthur^{3

7}, Paul Waring¹⁵, Shirley Carvosso²², Christopher Angel²³, David Gyorki^{19

24}, Benjamin Solomon^{3

7}, Gillian Mitchell^{7

25

26}, Sue Shanley²⁵, Prudence A Francis³, Sarah-Jane Dawson^{3

7

27}, Amy Haffenden²⁸, Erin Tidball²⁸, Mila Volchek²⁹, Jan Pyman²⁹, Mohammed Madadin^{13

30}, Jodie Leditschke^{13

31}, Stephen Cordner^{13

31}; Melbourne Melanoma Project; Australian Ovarian Cancer Study Group (AOCS); Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Mark Shackleton^{3

6

7}, David D Bowtell^{1

7

32}

Affiliations

¹ Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
² kConFab, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
³ Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁴ Department of Oncology, the Royal Women's Hospital, Parkville, Victoria, Australia.
⁵ Department of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.
⁶ Cancer Development and Treatment Laboratory, Research Department, Peter MacCallum Cancer, Melbourne, Victoria, Australia.
⁷ Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria, Australia.
⁸ Department of Pain and Palliative Care, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁹ Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁰ Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Victoria, Australia.
¹¹ Translational Breast Cancer Genomics and Therapeutics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹² The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
¹³ The Victorian Institute of Forensic Medicine, Southbank, Victoria, Australia.
¹⁴ Tobin Brothers Funerals, Victoria, Australia.
¹⁵ Department of Pathology, the University of Melbourne, Parkville, Victoria, Australia.
¹⁶ Department of Physiology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁷ Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁸ Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁹ Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁰ Molecular Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²¹ Bioinformatics and Cancer Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²² The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²³ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁴ The Department of Surgery, the University of Melbourne, Parkville, Victoria, Australia.
²⁵ The Jack Brockhoff Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁶ Hereditary Cancer Program, BC Cancer Agency, Vancouver, Canada.
²⁷ Molecular Biomarkers and Translational Genomics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁸ Department of Nursing, the Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁹ Department of Pathology, the Royal Women's Hospital, Parkville, Victoria, Australia.
³⁰ Department of Pathology, University of Dammam, Dammam, Saudi Arabia.
³¹ Department of Forensic Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
³² The Garvan Institute, Sydney, New South Wales, Australia.

PMID: 27617737
DOI: 10.1038/nbt.3674

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autopsy / methods*
Biotechnology
Community-Institutional Relations
Female
Genetic Techniques
Humans
Immunohistochemistry
Male
Models, Theoretical
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology*
Patient Selection
Time Factors