Intraoperative Vein Graft Preservation: What Is the Solution?

Ann Thorac Surg. 2016 Nov;102(5):1736-1746. doi: 10.1016/j.athoracsur.2016.05.097. Epub 2016 Sep 10.

Abstract

Saphenous vein graft (SVG) disease and subsequent vein graft failure remain a major problem after coronary artery bypass graft operations. In an effort to mitigate loss of endothelial viability, the vein is stored, intraoperatively, in a preservation solution. However, human SVG samples demonstrate endothelial denudation and dysfunction after such storage, the severity of which varies, depending on the medium. The paucity of clinical data evaluating preservation solutions is illustrated by the absence of optimal procedural protocol. This review evaluates the potential efficacy of different storage solutions in preserving vein grafts, in relation to a mechanistic understanding of SVG pathophysiology.

Publication types

  • Review

MeSH terms

  • Coronary Angiography
  • Coronary Artery Bypass / methods*
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / surgery*
  • Graft Occlusion, Vascular / prevention & control*
  • Humans
  • Intraoperative Period
  • Organ Preservation / methods*
  • Saphenous Vein / transplantation*