Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Quanyin Hu; Chenggen Qian; Wujin Sun; Jinqiang Wang; Zhaowei Chen; Hunter N Bomba; Hongliang Xin; Qundong Shen; Zhen Gu

doi:10.1002/adma.201603463

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Adv Mater. 2016 Nov;28(43):9573-9580. doi: 10.1002/adma.201603463. Epub 2016 Sep 14.

Authors

Quanyin Hu^{1

2}, Chenggen Qian^{1

2

3}, Wujin Sun^{1

2}, Jinqiang Wang^{1

2}, Zhaowei Chen^{1

2}, Hunter N Bomba^{1

2}, Hongliang Xin^{1

2

4}, Qundong Shen³, Zhen Gu^{1

2

5}

Affiliations

¹ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
² Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
³ Department of Polymer Science and Engineering and Key Laboratory of High Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
⁴ School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
⁵ Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

Abstract

A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication.

Keywords: biomimetics; drug delivery; multiple myeloma; platelets; thrombus.

MeSH terms

Animals
Biomimetic Materials / chemistry*
Biomimetic Materials / pharmacokinetics
Biomimetics
Blood Platelets / cytology
Bone and Bones / metabolism
Cell Line, Tumor
Cell Membrane / metabolism
Cellular Microenvironment
Disease Models, Animal
Drug Carriers / chemistry*
Drug Carriers / pharmacokinetics
Humans
Mice
Multiple Myeloma / complications
Multiple Myeloma / drug therapy*
Multiple Myeloma / metabolism
Multiple Myeloma / pathology*
Nanoparticles / chemistry*
Thrombosis / complications*
Thrombosis / drug therapy*

Substances

Drug Carriers

Abstract

MeSH terms

Substances

Grants and funding