Upcoming TAVI trials: rationale, design and impact on clinical practice

EuroIntervention. 2016 Sep 18;12(Y):Y51-5. doi: 10.4244/EIJV12SYA12.

Abstract

Over the past decade, approximately 15,000 patients have been randomised in clinical trials of transcatheter aortic valve implantation (TAVI), and as many patients will be randomised in ongoing and future investigations aimed at broadening indications, comparing devices, simplifying the procedure, and optimising clinical outcomes. The purpose of this review is to summarise the rationale and design of upcoming studies in the field of TAVI.

Publication types

  • Review

MeSH terms

  • Aortic Valve / diagnostic imaging
  • Aortic Valve / physiopathology
  • Aortic Valve / surgery*
  • Aortic Valve Insufficiency / diagnostic imaging
  • Aortic Valve Insufficiency / mortality
  • Aortic Valve Insufficiency / physiopathology
  • Aortic Valve Insufficiency / surgery*
  • Aortic Valve Stenosis / diagnostic imaging
  • Aortic Valve Stenosis / mortality
  • Aortic Valve Stenosis / physiopathology
  • Aortic Valve Stenosis / surgery*
  • Clinical Trials as Topic / methods*
  • Comorbidity
  • Evidence-Based Medicine
  • Heart Valve Prosthesis
  • Humans
  • Patient Selection
  • Prosthesis Design
  • Research Design
  • Risk Factors
  • Severity of Illness Index
  • Time Factors
  • Transcatheter Aortic Valve Replacement* / adverse effects
  • Transcatheter Aortic Valve Replacement* / instrumentation
  • Transcatheter Aortic Valve Replacement* / mortality
  • Treatment Outcome