Successful therapy of Candida pulcherrima fungemia in a premature newborn with liposomal amphotericin B and micafungin

Alexandra Mpakosi; Maria Siopi; Vasiliki Falaina; Nikolaos Siafakas; Emmanuel Roilides; Maria Kimouli; Martha Theodoraki; Paraskevi Karle; Joseph Meletiadis

doi:10.1016/j.mmcr.2016.08.002

Successful therapy of Candida pulcherrima fungemia in a premature newborn with liposomal amphotericin B and micafungin

Med Mycol Case Rep. 2016 Aug 3:12:24-7. doi: 10.1016/j.mmcr.2016.08.002. eCollection 2016 Jun.

Authors

Alexandra Mpakosi¹, Maria Siopi², Vasiliki Falaina³, Nikolaos Siafakas², Emmanuel Roilides⁴, Maria Kimouli¹, Martha Theodoraki³, Paraskevi Karle¹, Joseph Meletiadis²

Affiliations

¹ Department of Microbiology, General Hospital of Nikaia Agios Panteleimon, Athens 18454, Greece.
² Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens 12642, Greece.
³ Neonatal Intensive Care Unit, General Hospital of Nikaia Agios Panteleimon, Athens 18454, Greece.
⁴ Infectious Diseases Unit, 3rd Department of Pediatrics, Hippokration Hospital, Thessaloniki 54642, Greece.

Abstract

New Candida species may cause bloodstream infections challenging current therapeutic approaches because of unpredictable susceptibility and virulence. In the present report, we describe a fungemia case due to Candida pulcherrima in a premature neonate. After full in vitro diagnostic workup, the neonate was successfully treated with liposomal amphotericin B and micafungin achieving rapid fungal eradication from blood.

Keywords: Candidemia; Combination antifungal therapy; Liposomal amphotericin B; Micafungin; Neonate.