Pulmonary Kirsten Rat Sarcoma Virus Mutation Positive Mucinous Adenocarcinoma Arising in a Congenital Pulmonary Airway Malformation, Mixed Type 1 and 2

Ann Thorac Surg. 2016 Oct;102(4):e335-7. doi: 10.1016/j.athoracsur.2016.01.104.

Abstract

Congenital pulmonary airway malformation (CPAM) is a developmental abnormality of the lung, which results from an abnormality of branching during fetal development of the lung. We report the case of an 18 year-old woman who developed Kirsten rat sarcoma virus (KRAS) mutation positive mucinous adenocarcinoma of the lung (AC) in association with mixed CPAM type 1 and 2. This case is unique as KRAS mutation positive AC is present in a setting of both CPAM 1 and 2 in the same lesion.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / pathology*
  • Adenocarcinoma of Lung
  • Adenocarcinoma, Mucinous / pathology
  • Adenocarcinoma, Mucinous / surgery
  • Adolescent
  • Animals
  • Biopsy, Needle
  • Chronic Disease
  • Cystic Adenomatoid Malformation of Lung, Congenital / complications*
  • Cystic Adenomatoid Malformation of Lung, Congenital / genetics
  • Cystic Adenomatoid Malformation of Lung, Congenital / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Kirsten murine sarcoma virus / genetics*
  • Kirsten murine sarcoma virus / isolation & purification
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / pathology*
  • Mutation* / genetics
  • Pneumonectomy / methods
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • Rats
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / etiology
  • Thoracic Surgery, Video-Assisted / methods
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome

Substances

  • Kras protein, rat
  • Proto-Oncogene Proteins p21(ras)