Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4895-4898. doi: 10.1016/j.bmcl.2016.09.023. Epub 2016 Sep 9.

Abstract

Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.

Keywords: Bisindole; Cell cycle arrest; Cellular apoptosis; HT-29 cells; Inhibited cell proliferation; Melodinine V.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apocynaceae / chemistry*
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Cell Proliferation / drug effects
  • HT29 Cells
  • Humans
  • Secologanin Tryptamine Alkaloids / chemistry
  • Secologanin Tryptamine Alkaloids / pharmacology*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents
  • Secologanin Tryptamine Alkaloids
  • melodinine V