Cytomegalovirus sinusitis complicated by orbital apex syndrome in an immunocompromised host

Transpl Infect Dis. 2016 Dec;18(6):957-959. doi: 10.1111/tid.12616. Epub 2016 Nov 24.

Abstract

Sinusitis in immunocompromised patients can be caused by a wide variety of pathogens, primarily bacterial and fungal in nature. Tissue invasion can extend into the orbital apex and result in ophthalmoplegia and blindness. We report the first histologically proven case, to our knowledge, caused by cytomegalovirus infection.

Keywords: cytomegalovirus; orbital apex syndrome; sinusitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use
  • Biopsy
  • Blindness / etiology
  • Cytomegalovirus / isolation & purification*
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / pathology
  • Cytomegalovirus Infections / virology
  • Diplopia / etiology
  • Exophthalmos / etiology
  • Foscarnet / administration & dosage
  • Foscarnet / therapeutic use
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunocompromised Host
  • Male
  • Orbit / diagnostic imaging
  • Orbit / surgery
  • Sinusitis / complications*
  • Sinusitis / drug therapy
  • Sinusitis / pathology
  • Sinusitis / virology
  • Syndrome
  • Tomography, X-Ray Computed
  • Transplantation, Homologous / adverse effects
  • Trochlear Nerve Diseases / etiology
  • Viral Load
  • Virus Activation
  • Vision, Low / etiology

Substances

  • Antiviral Agents
  • Foscarnet