Abstract
Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of curacin A (2). Curacin A (2) is an antimitotic agent of cyanobacterial origin. The structure of curacin E was studied by interpretation of NMR data and the ECD spectrum. Curacin E has an ethylcarbonyl terminus in its side chain and inhibits the proliferation of P388 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Cyanobacteria / chemistry
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Cyclopropanes / chemistry
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Cyclopropanes / isolation & purification*
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Echinodermata / chemistry*
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Mitosis / drug effects
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Molecular Structure
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Thiazoles / chemistry
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Thiazoles / isolation & purification*
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Tubulin / metabolism
Substances
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Antineoplastic Agents
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Cyclopropanes
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Thiazoles
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Tubulin
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curacin E
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curacin A