Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy

Feng Kong; Hongbo Zhang; Xiangmeng Qu; Xu Zhang; Dong Chen; Ruihua Ding; Ermei Mäkilä; Jarno Salonen; Hélder A Santos; Mingtan Hai

doi:10.1002/adma.201602763

Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy

Adv Mater. 2016 Dec;28(46):10195-10203. doi: 10.1002/adma.201602763. Epub 2016 Sep 30.

Authors

Feng Kong¹, Hongbo Zhang^{1

2

3}, Xiangmeng Qu^{1

2

4}, Xu Zhang^{2

5}, Dong Chen², Ruihua Ding², Ermei Mäkilä⁶, Jarno Salonen⁶, Hélder A Santos³, Mingtan Hai^{1

2}

Affiliations

¹ Beijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
² Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
³ Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
⁴ School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China.
⁵ Cape Breton University, 1250 Grand Lake Road, Sydney, NS, B1P 6L2, Canada.
⁶ Laboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014, Turku, Finland.

PMID: 27689681
DOI: 10.1002/adma.201602763

Abstract

Gold nanorods, DNA origami, and porous silicon nanoparticle-functionalized biocompatible double emulsion are developed for versatile molecular targeted therapeutics and antibody combination therapy. This advanced photothermal responsive all-in-one biocompatible platform can be easily formed with great therapeutics loading capacity for different cancer treatments with synergism and multidrug resistance inhibition, which has great potential in advancing biomedical applications.

Keywords: DNA origami; biomedical applications; drug delivery; multidrug resistance inhibition; silicon nanoparticles.

MeSH terms

Antibodies / administration & dosage*
Antibodies / therapeutic use*
DNA / chemistry*
Emulsions / chemistry
Gold / chemistry*
Humans
Metal Nanoparticles / chemistry*
Nanomedicine / methods
Nanotubes / chemistry*
Neoplasms / drug therapy*
Neoplasms / immunology
Silicon / chemistry*

Substances

Antibodies
Emulsions
Gold
DNA
Silicon

Grants and funding

310892/ERC_/European Research Council/International