Programmed photosensitizer conjugated supramolecular nanocarriers with dual targeting ability for enhanced photodynamic therapy

Hongxin Tong; Jianwei Du; Huan Li; Qiao Jin; Youxiang Wang; Jian Ji

doi:10.1039/c6cc06439f

Programmed photosensitizer conjugated supramolecular nanocarriers with dual targeting ability for enhanced photodynamic therapy

Chem Commun (Camb). 2016 Sep 29;52(80):11935-11938. doi: 10.1039/c6cc06439f.

Authors

Hongxin Tong¹, Jianwei Du¹, Huan Li¹, Qiao Jin¹, Youxiang Wang¹, Jian Ji¹

Affiliation

¹ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. [email protected] [email protected].

PMID: 27711433
DOI: 10.1039/c6cc06439f

Abstract

A programmed supramolecular nanocarrier was developed for multistage targeted photodynamic therapy. This smart nanocarrier exhibited enhanced cellular uptake and controlled mitochondria targeting, as well as an excellent photodynamic therapeutic effect after light irradiation.

MeSH terms

Amino Acid Sequence
Apoptosis / drug effects
Breast Neoplasms / drug therapy
Breast Neoplasms / pathology
Cell Proliferation / drug effects
Chlorophyllides
Drug Carriers / chemistry*
Female
Humans
Light
MCF-7 Cells
Microscopy, Confocal
Mitochondria / drug effects
Mitochondria / metabolism
Nanoparticles / chemistry*
Peptides / chemistry
Photochemotherapy
Photosensitizing Agents / chemistry*
Photosensitizing Agents / metabolism
Photosensitizing Agents / toxicity
Porphyrins / chemistry
beta-Cyclodextrins / chemistry

Substances

Chlorophyllides
Drug Carriers
Peptides
Photosensitizing Agents
Porphyrins
beta-Cyclodextrins
phytochlorin
betadex