Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

Kaori Tsukakoshi; Yuri Ikuta; Koichi Abe; Wataru Yoshida; Keisuke Iida; Yue Ma; Kazuo Nagasawa; Koji Sode; Kazunori Ikebukuro

doi:10.1039/c6cc07552e

Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

Chem Commun (Camb). 2016 Oct 18;52(85):12646-12649. doi: 10.1039/c6cc07552e.

Authors

Kaori Tsukakoshi¹, Yuri Ikuta¹, Koichi Abe¹, Wataru Yoshida², Keisuke Iida³, Yue Ma¹, Kazuo Nagasawa¹, Koji Sode¹, Kazunori Ikebukuro¹

Affiliations

¹ Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. [email protected].
² School of Biotechnology and Bioscience, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo 192-0982, Japan.
³ Graduate School of Science and Engineering, Saitama University, Shimo-okubo 255, Sakura-ku, Saitama 338-8570, Japan.

PMID: 27713935
DOI: 10.1039/c6cc07552e

Abstract

We report that a G-quadruplex-specific compound induced structural changes in G-quadruplex-forming DNA aptamers and stabilized the folded structures, making them suitable for targeted proteins and enhancing their binding properties.