Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36

Stem Cell Reports. 2016 Nov 8;7(5):869-883. doi: 10.1016/j.stemcr.2016.09.002. Epub 2016 Oct 6.

Abstract

The development of human erythroid cells has been mostly examined in models of adult hematopoiesis, while their early derivation during embryonic and fetal stages is largely unknown. We observed the development and maturation of erythroblasts derived from human pluripotent stem cells (hPSCs) by an efficient co-culture system. These hPSC-derived early erythroblasts initially showed definitive characteristics with a glycophorin A+ (GPA+) CD34lowCD36- phenotype and were distinct from adult CD34+ cell-derived ones. After losing CD34 expression, early GPA+CD36- erythroblasts matured into GPA+CD36low/+ stage as the latter expressed higher levels of β-globin along with a gradual loss of mesodermal and endothelial properties, and terminally suppressed CD36. We establish a unique in vitro model to trace the early development of hPSC-derived erythroblasts by serial expression of CD34, GPA, and CD36. Our findings may provide insight into the understanding of human early erythropoiesis and, ultimately, therapeutic potential.

Keywords: CD34; CD36; GPA; development; endothelial cells; erythroblasts; erythropoiesis; hESC; hematopoiesis; hiPSC.

MeSH terms

  • Antigens, CD34 / metabolism*
  • Biomarkers
  • CD36 Antigens / metabolism*
  • Cell Differentiation*
  • Cells, Cultured
  • Cluster Analysis
  • Coculture Techniques
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Erythroblasts / cytology*
  • Erythroblasts / metabolism*
  • Gene Expression
  • Gene Expression Profiling
  • Glycophorins / metabolism*
  • Hematopoiesis / genetics
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Phenotype
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*
  • Signal Transduction

Substances

  • Antigens, CD34
  • Biomarkers
  • CD36 Antigens
  • Glycophorins