IRGB10 Exposes Bacteria's Intimate Secrets

Florian Hoss; Christina F Budden; Eicke Latz

doi:10.1016/j.devcel.2016.09.026

IRGB10 Exposes Bacteria's Intimate Secrets

Dev Cell. 2016 Oct 10;39(1):7-8. doi: 10.1016/j.devcel.2016.09.026.

Authors

Florian Hoss¹, Christina F Budden¹, Eicke Latz²

Affiliations

¹ Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany.
² Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: [email protected].

PMID: 27728782
DOI: 10.1016/j.devcel.2016.09.026

Abstract

When bacteria infect a cell, the bacterial membrane partially shields microbial structures from the immune system, preventing detection and clearance. In a recent issue of Cell, Man et al. (2016) show that the interferon-inducible protein IRGB10 liberates bacterial ligands for sensing by both the AIM2 and the non-canonical NLRP3 inflammasomes.

Publication types

Comment

MeSH terms

Bacteria / metabolism*
Inflammasomes / immunology*

Substances

Inflammasomes