Up to now there is no screening test suitable for coronary heart disease (CHD) among population. 38 cases of CHD diagnosed by electrocardiographic bicycle exercise and 71 cases with negative results as controls were studied concurrently to evaluate the screening test of CHD. According to the significant difference between the two groups, the ratio of TC/HDL-C.HDL-C/TC.LDL-C/HDL-C.HDL2-C/HDL3-C were selected to evaluate their validity and predictivity etc, on several cutoff vale respectively. TC/HDL-C and HDL2-C/HDL3-C were used in parallel to promote the detective value of CHD to 92%. TC/HDL-C was only selected in stepwise regression formula, so the positive likelihood of five-grade value of TC/HDL-C was calculated and different prior-test probability was estimated to predict the post-test probability of CHD. As a result cutoff value 3.2 of TC/HDL-C could be determined as atherogenic index in chinese population.