Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial

Leukemia. 2017 Feb;31(2):510-514. doi: 10.1038/leu.2016.298. Epub 2016 Oct 26.

Authors

M Larrayoz¹, M J J Rose-Zerilli¹, L Kadalayil², H Parker¹, S Blakemore¹, J Forster¹, Z Davis³, A J Steele¹, A Collins², M Else⁴, D Catovsky⁴, D G Oscier³, J C Strefford¹

Affiliations

¹ Caner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
² Genetic Epidemiology and Bioinformatics, Faculty of Medicine, University of Southampton, Southampton, UK.
³ Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
⁴ Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

No abstract available

Publication types

Clinical Trial
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / mortality
Mutation*
Prognosis
Receptor, Notch1 / genetics*
Survival Analysis

Substances

NOTCH1 protein, human
Receptor, Notch1

Grants and funding