Current best practice in the evaluation and management of malignant pleural effusions

Ther Adv Respir Dis. 2017 Feb;11(2):105-114. doi: 10.1177/1753465816671697. Epub 2016 Oct 24.

Abstract

Malignant pleural effusions (MPEs) are an important cause of cancer-related mortality and morbidity. It is a heterogeneous group of conditions, which leads to debilitating symptoms and confers a poor prognosis. Recent well-designed randomized trials have provided a broader evidence base for an expanding range of treatment options. Together, with new prognostic scoring systems and a greater understanding of how different patient phenotypes respond to treatment, this allows greater personalization of management. This article will discuss the current evidence on evaluation and management of MPEs.

Keywords: indwelling pleural catheter; malignant; mesothelioma; pleural disease; pleural effusion; pleurodesis.

Publication types

  • Review

MeSH terms

  • Humans
  • Phenotype
  • Pleural Effusion, Malignant / mortality
  • Pleural Effusion, Malignant / physiopathology
  • Pleural Effusion, Malignant / therapy*
  • Precision Medicine / methods*
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Research Design