RNA-Seeded Functional Amyloids Balance Growth and Survival

Shawn M Lyons; Paul Anderson

doi:10.1016/j.devcel.2016.10.005

RNA-Seeded Functional Amyloids Balance Growth and Survival

Dev Cell. 2016 Oct 24;39(2):131-132. doi: 10.1016/j.devcel.2016.10.005.

Authors

Shawn M Lyons¹, Paul Anderson²

Affiliations

¹ Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
² Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

Abstract

In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition.

Publication types

Comment

MeSH terms

Amyloid*
RNA*

Substances

Amyloid
RNA

Abstract

Publication types

MeSH terms

Substances

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