Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody-associated vasculitis

Federico Alberici; Rona M Smith; Mariana Fonseca; Lisa C Willcocks; Rachel B Jones; Julia U Holle; Stefan Wieczorek; Thomas Neumann; Davide Martorana; Gina Gregorini; Renato A Sinico; Annette Bruchfeld; Iva Gunnarsson; Sophie Ohlsson; Bo Baslund; Vladimir Tesar; Zdenka Hruskova; Maria C Cid; Augusto Vaglio; Paul A Lyons; Kenneth G C Smith; David R W Jayne

doi:10.1016/j.jaci.2016.08.051

Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody-associated vasculitis

J Allergy Clin Immunol. 2017 May;139(5):1684-1687.e10. doi: 10.1016/j.jaci.2016.08.051. Epub 2016 Oct 22.

Authors

Federico Alberici¹, Rona M Smith², Mariana Fonseca², Lisa C Willcocks², Rachel B Jones², Julia U Holle³, Stefan Wieczorek⁴, Thomas Neumann⁵, Davide Martorana⁶, Gina Gregorini⁷, Renato A Sinico⁸, Annette Bruchfeld⁹, Iva Gunnarsson¹⁰, Sophie Ohlsson¹¹, Bo Baslund¹², Vladimir Tesar¹³, Zdenka Hruskova¹³, Maria C Cid¹⁴, Augusto Vaglio¹⁵, Paul A Lyons², Kenneth G C Smith², David R W Jayne²

Affiliations

¹ Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Nephrology and Immunology Unit, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Milan, Italy; Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy. Electronic address: [email protected].
² Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
³ Department of Rheumatology, Immunology and Vasculitis Clinic, Klinikum Bad Bramstedt, Bad Bramstedt, Germany.
⁴ Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
⁵ Department of Internal Medicine III, Jena University Hospital, Jena, Germany.
⁶ Medical Genetics Unit, University Hospital of Parma, Parma, Italy.
⁷ Department of Nephrology, A.O. Spedali Civili, Brescia, Italy.
⁸ Nephrology and Immunology Unit, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca (School of Medicine and Surgery), Monza, Italy.
⁹ Department of Renal Medicine, Karolinska University Hospital and Karolinska Institute, Solna, Sweden.
¹⁰ Department of Medicine, Unit of Rheumatology, Karolinska University Hospital, Karoliska Institute, Solna, Sweden.
¹¹ Department of Nephrology and Transplantation, Skane University Hospital, Gothenburg, Sweden.
¹² Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
¹³ Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
¹⁴ Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain.
¹⁵ Nephrology Unit, University Hospital of Parma, Parma, Italy.

PMID: 27780742
DOI: 10.1016/j.jaci.2016.08.051

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy*
Antirheumatic Agents / therapeutic use*
B-Cell Activating Factor / genetics*
B-Lymphocytes / drug effects*
B-Lymphocytes / physiology
Biomarkers, Pharmacological
Cohort Studies
Female
Humans
Lymphocyte Depletion
Male
Middle Aged
Polymorphism, Single Nucleotide
Regulatory Sequences, Nucleic Acid / genetics
Rituximab / therapeutic use*

Substances

Antirheumatic Agents
B-Cell Activating Factor
Biomarkers, Pharmacological
TNFSF13B protein, human
Rituximab

Grants and funding

MR/L019027/1/MRC_/Medical Research Council/United Kingdom