p53 partners with RNA in the DNA damage response

Maite Huarte

doi:10.1038/ng.3702

p53 partners with RNA in the DNA damage response

Nat Genet. 2016 Oct 27;48(11):1298-1299. doi: 10.1038/ng.3702.

Author

Maite Huarte¹

Affiliation

¹ Center for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, University of Navarra and the Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain.

PMID: 27787509
DOI: 10.1038/ng.3702

Abstract

Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.

MeSH terms

Cyclin-Dependent Kinase Inhibitor p21 / genetics*
DNA Damage / genetics
Humans
Promoter Regions, Genetic
Protein Stability
RNA, Long Noncoding / genetics*
Tumor Suppressor Protein p53 / biosynthesis
Tumor Suppressor Protein p53 / genetics*

Substances

Cyclin-Dependent Kinase Inhibitor p21
DINOL lncRNA, human
RNA, Long Noncoding
TP53 protein, human
Tumor Suppressor Protein p53