Redox-Neutral Rh(III)-Catalyzed Olefination of Carboxamides with Trifluoromethyl Allylic Carbonate

J Org Chem. 2016 Nov 18;81(22):11353-11359. doi: 10.1021/acs.joc.6b02485. Epub 2016 Nov 3.

Abstract

The rhodium(III)-catalyzed olefination of various carboxamides with α-CF3-substituted allylic carbonate is described. This reaction provides direct access to linear CF3-allyl frameworks with complete trans-selectivity. In particular, a rhodium catalyst provided Heck-type γ-CF3-allylation products via the β-O-elimination of rhodacycle intermediate and subsequent olefin migration process.

Publication types

  • Research Support, Non-U.S. Gov't