Criteria for the validity of clinical trials of treatments of cohorts of cancer patients based on the Hardin Jones principle

Proc Natl Acad Sci U S A. 1989 Sep;86(18):6835-7. doi: 10.1073/pnas.86.18.6835.

Abstract

With the assumption of the validity of the Hardin Jones principle that the death rate of members of a homogeneous cohort of cancer patients is constant, three criteria for the validity of clinical trials of cancer treatments are formulated. These criteria are satisfied by most published clinical trials, but one trial was found to violate all three, rendering the validity of its reported results uncertain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascorbic Acid / therapeutic use
  • Clinical Trials as Topic / methods*
  • Cohort Studies*
  • Colonic Neoplasms / drug therapy
  • Colorectal Neoplasms / drug therapy
  • Double-Blind Method
  • Humans
  • Models, Statistical*
  • Neoplasms / drug therapy*

Substances

  • Ascorbic Acid