Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts

Masaru Kondo; Mami Sugimoto; Shuichi Nakamura

doi:10.1039/c6cc07982b

Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts

Chem Commun (Camb). 2016 Nov 15;52(93):13604-13607. doi: 10.1039/c6cc07982b.

Authors

Masaru Kondo¹, Mami Sugimoto², Shuichi Nakamura¹

Affiliations

¹ Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. [email protected] and Frontier Research Institute for Material Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
² Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. [email protected].

PMID: 27808296
DOI: 10.1039/c6cc07982b

Abstract

The catalytic enantioselective Mannich-type reaction of dichloroacetonitrile with imines has been developed. Good yields and enantioselectivity were observed for the reaction with various imines using chiral bis(imidazoline) catalysts. β-Aminonitriles or β-aminoamide were obtained from products without the loss of enantiopurity.