Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats

J Infect Dis. 2017 Jan 15;215(2):209-213. doi: 10.1093/infdis/jiw534.

Abstract

To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuVJL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuVJL5-F/HNBMV) virus and rMuVJL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuVJL5 infection had cross-neutralizing activity against rMuVJL5-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.

Keywords: cross-reactive antibodies; mumps virus; neutralizing antibodies; viral envelope proteins; zoonoses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Chiroptera / virology*
  • Cross Reactions*
  • Female
  • Humans
  • Mice, Inbred BALB C
  • Middle Aged
  • Mumps virus / immunology*
  • Mumps virus / isolation & purification
  • Young Adult

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral