VHL Brings Warburg into the Memory Spotlight

Greg M Delgoffe

doi:10.1016/j.immuni.2016.11.001

VHL Brings Warburg into the Memory Spotlight

Immunity. 2016 Nov 15;45(5):953-955. doi: 10.1016/j.immuni.2016.11.001.

Author

Greg M Delgoffe¹

Affiliation

¹ Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15262; Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232. Electronic address: [email protected].

PMID: 27851921
DOI: 10.1016/j.immuni.2016.11.001

Abstract

Previous studies suggest mitochondrial metabolic pathways are essential for the generation of memory T cells. In this issue of Immunity, Phan et al. (2016) describe the formation of memory in T cells with constitutive glycolytic metabolism, suggesting that fuel does not necessarily dictate function.

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MeSH terms

Glycolysis*
Mitochondria*
T-Lymphocytes