Exploring the Genetic Etiology of Trust in Adolescents: Combined Twin and DNA Analyses

Twin Res Hum Genet. 2016 Dec;19(6):638-646. doi: 10.1017/thg.2016.84.

Abstract

Behavioral traits generally show moderate to strong genetic influence, with heritability estimates of around 50%. Some recent research has suggested that trust may be an exception because it is more strongly influenced by social interactions. In a sample of over 7,000 adolescent twins from the United Kingdom's Twins Early Development Study, we found broad sense heritability estimates of 57% for generalized trust and 51% for trust in friends. Genomic-relatedness-matrix restricted maximum likelihood (GREML) estimates in the same sample indicate that 21% of the narrow sense genetic variance can be explained by common single nucleotide polymorphisms for generalized trust and 43% for trust in friends. As expected, this implies a large amount of unexplained heritability, although power is low for estimating DNA-based heritability. The missing heritability may be accounted for by interactions between DNA and the social environment during development or via gene-environment correlations with rare variants. How these genes and environments correlate seem especially important for the development of trust.

Keywords: DNA-based heritability; heritability; trust; twin design.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Friends / psychology
  • Genetic Variation
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics
  • Social Environment*
  • Trust / psychology*
  • Twins / genetics*
  • Twins / psychology
  • United Kingdom
  • Young Adult