Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing NDM-9 and in Escherichia coli from the Same Animal

Antimicrob Agents Chemother. 2017 Jan 24;61(2):e01444-16. doi: 10.1128/AAC.01444-16. Print 2017 Feb.

Abstract

We report the presence of mcr-1 in Escherichia coli and carbapenem-resistant Cronobacter sakazakii from the same diseased chicken. The mcr-1 gene linked with ISApl1 was located on two different IncI2 plasmids, including one multidrug plasmid in E. coli, whereas fosA3-blaNDM-9 was on an IncB/O plasmid in C. sakazakii The development of the fosA3-blaNDM-9 resistance region was mediated by IS26 The colocation of mcr-1 or blaNDM-9 with other resistance genes will accelerate the dissemination of the two genes.

Keywords: Cronobacter sakazakii; NDM-9; chicken; insertion sequences; mcr-1.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Chickens / microbiology
  • China
  • Colistin / pharmacology*
  • Cronobacter sakazakii / drug effects*
  • Cronobacter sakazakii / genetics
  • Cronobacter sakazakii / isolation & purification
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics*
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / veterinary
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary
  • Escherichia coli Proteins / genetics*
  • Microbial Sensitivity Tests
  • Plasmids / drug effects
  • Plasmids / genetics
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • beta-Lactamases
  • Colistin