Abstract
A 17-year-old male with ADHD who was treated with sertraline and lisdexamfetamine presented with transient episodes of speech impairment and right-sided hemiparesis preceded by headaches. Magnetic resonance imaging revealed three cerebral ischaemic lesions. Treatment was initiated with aspirin and discontinued with lisdexamfetamine. In the literature a causal relationship between treatment with central stimulants and the development of cerebrovascular events has not been substantiated. Vasospasm and paroxystic tachycardia may be associated with the event, but lisdexamfetamine and sertraline cannot be ruled out as risk factors.
MeSH terms
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Adolescent
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Attention Deficit Disorder with Hyperactivity / drug therapy
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Central Nervous System Stimulants / adverse effects*
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Central Nervous System Stimulants / therapeutic use
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Cerebral Infarction / chemically induced*
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Cerebral Infarction / diagnostic imaging
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Cerebral Infarction / drug therapy
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Depressive Disorder / drug therapy
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Diffusion Magnetic Resonance Imaging
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Humans
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Lisdexamfetamine Dimesylate / adverse effects*
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Lisdexamfetamine Dimesylate / therapeutic use
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Male
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Selective Serotonin Reuptake Inhibitors / adverse effects*
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Selective Serotonin Reuptake Inhibitors / therapeutic use
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Sertraline / adverse effects*
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Sertraline / therapeutic use
Substances
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Central Nervous System Stimulants
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Serotonin Uptake Inhibitors
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Sertraline
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Lisdexamfetamine Dimesylate