Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells

Haematologica. 2017 Mar;102(3):e100-e103. doi: 10.3324/haematol.2016.153197. Epub 2016 Nov 17.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics
  • Antigens, CD / immunology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism*
  • B-Lymphocytes / pathology
  • Bystander Effect / genetics*
  • Bystander Effect / immunology
  • Extracellular Vesicles / chemistry*
  • Extracellular Vesicles / immunology
  • Extracellular Vesicles / pathology
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / immunology
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / immunology
  • RNA Splicing Factors / genetics
  • RNA Splicing Factors / immunology
  • RNA Transport
  • RNA, Messenger / genetics*
  • RNA, Messenger / immunology
  • Signal Transduction
  • Syk Kinase / genetics
  • Syk Kinase / immunology
  • Toll-Like Receptor 9 / genetics
  • Toll-Like Receptor 9 / immunology
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / immunology
  • src-Family Kinases / genetics
  • src-Family Kinases / immunology

Substances

  • Antigens, CD
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • RNA Splicing Factors
  • RNA, Messenger
  • TCL1A protein, human
  • TLR9 protein, human
  • Toll-Like Receptor 9
  • Tumor Necrosis Factor-alpha
  • SYK protein, human
  • Syk Kinase
  • lyn protein-tyrosine kinase
  • src-Family Kinases