Tor-dependent post-transcriptional regulation of autophagy: Implications for cancer therapeutics

Guowu Hu; Travis McQuiston; Amélie Bernard; Yoon-Dong Park; Jin Qiu; Ali Vural; Nannan Zhang; Scott R Waterman; Nathan H Blewett; Timothy G Myers; John H Kehrl; Gulbu Uzel; Daniel J Klionsky; Peter R Williamson

doi:10.1080/23723556.2015.1078923

Tor-dependent post-transcriptional regulation of autophagy: Implications for cancer therapeutics

Mol Cell Oncol. 2015 Sep 16;3(5):e1078923. doi: 10.1080/23723556.2015.1078923. eCollection 2016.

Authors

Affiliations

¹ Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
² Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
³ Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
⁴ Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD, USA.
⁵ Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , MD, USA.

Abstract

Paradoxically, both anticancer immunosurveillance and tumor progression have been associated with intact autophagy, which is regulated by the target of rapamycin (Tor1). Here, we describe the potential impact on the design of cancer therapeutics of a newly described highly conserved post-transcriptional mechanism whereby Tor regulates autophagy.

Keywords: Autoimmunity; Tor; autophagy; oncology; pharmacology; phosphorylation; tumor immunology.