Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A

Br J Haematol. 2018 Mar;180(5):741-744. doi: 10.1111/bjh.14431. Epub 2016 Nov 10.
No abstract available

Keywords: DNMT3A; SOCS1; STAT3; TP53; breast implant-associated anaplastic large-cell lymphoma; somatic mutations.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Breast Implants / adverse effects*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methyltransferase 3A
  • Female
  • Frameshift Mutation / genetics
  • Genes, p53 / genetics*
  • Humans
  • Janus Kinases / genetics
  • Lymphoma, Large-Cell, Anaplastic / genetics*
  • Middle Aged
  • Mutation / genetics*
  • Mutation, Missense / genetics
  • STAT3 Transcription Factor / genetics
  • Signal Transduction / genetics
  • Suppressor of Cytokine Signaling 1 Protein / genetics

Substances

  • DNMT3A protein, human
  • SOCS1 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Suppressor of Cytokine Signaling 1 Protein
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
  • Janus Kinases