Quality of life of patients with recurrent respiratory papillomatosis

Michel R M San Giorgi; Leena-Maija Aaltonen; Heikki Rihkanen; Robin E A Tjon Pian Gi; Bernard F A M van der Laan; Josette E H M Hoekstra-Weebers; Frederik G Dikkers

doi:10.1002/lary.26413

Quality of life of patients with recurrent respiratory papillomatosis

Laryngoscope. 2017 Aug;127(8):1826-1831. doi: 10.1002/lary.26413. Epub 2016 Nov 15.

Authors

Michel R M San Giorgi^{1

2

3}, Leena-Maija Aaltonen⁴, Heikki Rihkanen⁴, Robin E A Tjon Pian Gi^{1

2

3}, Bernard F A M van der Laan^{1

2}, Josette E H M Hoekstra-Weebers⁵, Frederik G Dikkers^{1

2

3}

Affiliations

¹ Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
² Cancer Research Center, University of Groningen, Groningen, the Netherlands.
³ Groningen Papilloma Studies, University of Groningen, the Netherlands.
⁴ Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
⁵ Wenckebach Institute, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

PMID: 27861969
DOI: 10.1002/lary.26413

Abstract

Objectives/hypothesis: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy.

Study design: Prospective cross-sectional questionnaire research.

Methods: Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use. Descriptive analyses, χ² tests, t tests, analysis of variance tests, and Pearson correlations were computed to describe the study population and to examine differences between groups.

Results: RRP patients had significantly higher mean scores on depression, health-related QoL (15D) and on voice problems (VHI), and significantly lower mean scores on anxiety than controls. Dutch patients had more pain and a decreased general health perception (RAND-36) than controls. Dutch patients and older patients were more depressed, women were more anxious, older patients had lower health-related QoL, and smoking was significantly associated with voice handicap. Patients who had received psychosocial care had significantly higher HADS-depression mean scores than patients who did not receive psychosocial care.

Conclusions: Having RRP has significant effect on voice-related QoL and depression, but has no negative effect on anxiety and health-related QoL. Risk factors for decreased functioning are different than previously hypothesized by many authors. Prevention should be aimed at these risk factors.

Level of evidence: 4. Laryngoscope, 127:1826-1831, 2017.

Keywords: Recurrent respiratory papillomatosis; psychosocial distress; quality of life; recurrent respiratory papillomatosis.

Publication types

Multicenter Study

MeSH terms

Adult
Cross-Sectional Studies
Female
Humans
Male
Papillomavirus Infections* / complications
Papillomavirus Infections* / diagnosis
Papillomavirus Infections* / therapy
Prospective Studies
Quality of Life*
Respiratory Tract Infections* / complications
Respiratory Tract Infections* / diagnosis
Respiratory Tract Infections* / therapy
Self Report*

Supplementary concepts

Recurrent respiratory papillomatosis