A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

Cytokine. 2017 Feb:90:96-99. doi: 10.1016/j.cyto.2016.10.018. Epub 2016 Nov 16.

Abstract

An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

Keywords: AIDS; HIV-1; IL-18; IL-18BP; Long-Term Non-Progressors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood*
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / therapy
  • CD4 Lymphocyte Count
  • Female
  • HIV-1*
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Intercellular Signaling Peptides and Proteins / immunology
  • Male

Substances

  • Intercellular Signaling Peptides and Proteins
  • interleukin-18 binding protein