Radical scavenging and antibacterial activity of caffemides against gram positive, gram negative and clinical drug resistance bacteria

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5943-5946. doi: 10.1016/j.bmcl.2016.10.089. Epub 2016 Oct 31.

Abstract

A new series of caffemide were synthesized and their antioxidant and antibacterial activities were explored. Antioxidant and antibacterial activities were measured of different structures of caffemide containing different functional groups. Anti-oxidative caffemides 1b and 1g showed significantly higher activity against different bacteria with MIC values less than 50μg/ml. These anti-oxidative and antibacterial properties of caffemides might be helpful for the treatment of secondary infections and discovery of new antibiotics.

Keywords: Caffemide; DPPH; M. smegmatis; P. aeruginosa; S. aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminophenols / chemical synthesis
  • Aminophenols / chemistry
  • Aminophenols / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Caffeic Acids / chemical synthesis
  • Caffeic Acids / chemistry
  • Caffeic Acids / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Resistance, Bacterial / drug effects*
  • Free Radical Scavengers / chemical synthesis
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Aminophenols
  • Anti-Bacterial Agents
  • Caffeic Acids
  • Free Radical Scavengers