Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues

Robert J Desnick; Norman W Barton; Scott Furbish; Gregory A Grabowski; Stefan Karlsson; Edwin H Kolodny; Jeffrey A Medin; Gary J Murray; Pramod K Mistry; Marc C Patterson; Raphael Schiffmann; Neal J Weinreb

doi:10.1016/j.ymgme.2016.10.010

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues

Mol Genet Metab. 2017 Jan-Feb;120(1-2):1-7. doi: 10.1016/j.ymgme.2016.10.010. Epub 2016 Nov 12.

Authors

Affiliations

¹ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: [email protected].
² Neuroscience Therapeutic Area, Shire, Lexington, MA 02421, USA.
³ Clearwater, FL, USA.
⁴ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
⁵ Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.
⁶ Department of Neurology, New York University School of Medicine, New York, NY 10012, USA.
⁷ Departments of Pediatrics and Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
⁸ Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
⁹ Departments of Medicine, Pediatrics and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.
¹⁰ Departments of Neurology, Pediatrics and Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA.
¹¹ Institute of Metabolic Disease, Baylor Research Institute, Dallas, TX 75087, USA.
¹² Department of Human Genetics and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

PMID: 27866832
DOI: 10.1016/j.ymgme.2016.10.010

Abstract

To celebrate the research visions and accomplishments of the late Roscoe O. Brady (1923-2016), remembrance commentaries were requested from several of his postdoctoral research fellows and colleagues. These commentaries not only reflect on the accomplishments of Dr. Brady, but they also share some of the backstories and experiences working in the Brady laboratory. They provide insights and perspectives on Brady's research activities, and especially on his efforts to develop an effective treatment for patients with Type 1 Gaucher disease. These remembrances illuminate Brady's efforts to implement the latest scientific advances with an outstanding team of young co-investigators to develop and demonstrate the safety and effectiveness of the first enzyme replacement therapy for a lysosomal storage disease. Brady's pursuit and persistence in accomplishing his research objectives provide insights into this remarkably successful physician scientist who paved the way for the development of treatments for patients with other lysosomal storage diseases.

Publication types

Biography
Festschrift
Historical Article

MeSH terms

Enzyme Replacement Therapy / history*
Enzyme Replacement Therapy / methods
Gaucher Disease / drug therapy
History, 20th Century
History, 21st Century
Humans
Lysosomal Storage Diseases / drug therapy*
Research Personnel

Personal name as subject

Roscoe Owen Brady