T Cell Immunity to Varicella-Zoster Virus in the Setting of Advanced HIV and Multiple Varicella-Zoster Virus Recurrences

Viral Immunol. 2017 Jan/Feb;30(1):77-80. doi: 10.1089/vim.2016.0097. Epub 2016 Nov 21.

Abstract

A woman presented with at least four manifestations of varicella-zoster virus (VZV) infection, including central nervous system vasculitis, during her first 2 years of HIV infection. We evaluated her CD4 T cell responses to VZV given the infrequency with which multiple recurrences of VZV occurred, especially following immune reconstitution on antiretroviral therapy.

Keywords: CD4 response; HIV; VZV vasculitis; cellular immunology; herpes zoster; varicella-zoster virus.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • CD4-Positive T-Lymphocytes / immunology*
  • Female
  • HIV Infections / complications*
  • Herpes Zoster / immunology*
  • Herpesvirus 3, Human / immunology*
  • Humans
  • Recurrence