[Cell strains of A431 epidermoid carcinoma with altered epidermal growth factor reception]

Tsitologiia. 1989 Mar;31(3):319-23.
[Article in Russian]

Abstract

Epidermal growth factor inhibits proliferation of A431 cells when added to the cultural medium. Strains of A431 cells, resistant to EGF (800 ng/ml), were obtained by one-step selection after the treatment of these cells by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG). Two of the obtained strains differ from the initial line in the EGF reception.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology*
  • Cell Division / drug effects
  • Cell Line
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Drug Resistance
  • Epidermal Growth Factor / metabolism
  • Epidermal Growth Factor / pharmacology
  • ErbB Receptors / drug effects
  • ErbB Receptors / metabolism*
  • Humans
  • Iodine Radioisotopes
  • Methylnitronitrosoguanidine / pharmacology
  • Tumor Cells, Cultured

Substances

  • Iodine Radioisotopes
  • Methylnitronitrosoguanidine
  • Epidermal Growth Factor
  • ErbB Receptors