Redox Paradox: Can Hypoxia Heal Ischemic Hearts?

Nuno Guimarães-Camboa; Sylvia M Evans

doi:10.1016/j.devcel.2016.11.007

Redox Paradox: Can Hypoxia Heal Ischemic Hearts?

Dev Cell. 2016 Nov 21;39(4):392-394. doi: 10.1016/j.devcel.2016.11.007.

Authors

Nuno Guimarães-Camboa¹, Sylvia M Evans²

Affiliations

¹ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
² Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: [email protected].

Abstract

Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.

Publication types

Comment

MeSH terms

Animals
Hypoxia
Mice
Myocardial Infarction*
Myocytes, Cardiac*
Oxidation-Reduction
Regeneration

Abstract

Publication types

MeSH terms

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