The peritoneal surface is a frequent site of recurrence following surgery for gastric cancer. A systematic review and random effect analysis was undertaken to analyze current literature regarding the role of adjuvant intraperitoneal chemotherapy in gastric cancer. While pooled analysis supports the use of adjuvant IP chemotherapy in resectable gastric cancer, maximal benefit occured with intra-operative delivery, and possibly the use of MMC. J. Surg. Oncol. 2017;115:192-201. © 2016 Wiley Periodicals, Inc.
Keywords: adjuvant regional chemotherapy; gastrointestinal malignancies; heated intraperitoneal chemotherapy (HIPEC); peritoneal carcinomatosis; systematic review.
© 2016 Wiley Periodicals, Inc.