Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?

A L Hartley; J M Birch; A M Kelsey; H B Marsden; M Harris; M D Teare

doi:10.1016/0165-4608(89)90090-3

Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?

Cancer Genet Cytogenet. 1989 Oct 15;42(2):221-6. doi: 10.1016/0165-4608(89)90090-3.

Authors

A L Hartley¹, J M Birch, A M Kelsey, H B Marsden, M Harris, M D Teare

Affiliation

¹ Department of Epidemiology and Social Oncology, Christie Hospital, Manchester, England.

PMID: 2790757
DOI: 10.1016/0165-4608(89)90090-3

Abstract

The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni cancer family syndrome.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Breast Neoplasms / genetics
Child
Dysgerminoma / genetics*
Female
Humans
Infant
Male
Middle Aged
Neoplastic Syndromes, Hereditary / genetics*
Ovarian Neoplasms / genetics*
Sarcoma / genetics
Soft Tissue Neoplasms / genetics
Syndrome
Testicular Neoplasms / genetics*