Isochromosome 12p in mediastinal germ cell tumor

P Dal Cin; A Drochmans; P Moerman; H Van den Berghe

doi:10.1016/0165-4608(89)90092-7

Isochromosome 12p in mediastinal germ cell tumor

Cancer Genet Cytogenet. 1989 Oct 15;42(2):243-51. doi: 10.1016/0165-4608(89)90092-7.

Authors

P Dal Cin¹, A Drochmans, P Moerman, H Van den Berghe

Affiliation

¹ Centre for Human Genetics, University of Leuven, Belgium.

PMID: 2790759
DOI: 10.1016/0165-4608(89)90092-7

Abstract

The occurrence of an i(12p) in an extragonadal mediastinal germ cell tumor indicates that this chromosome change, which is characteristic for testicular germ cell tumors, can also occur in germ cell tumors present elsewhere in the body. In addition, the karyotype in this patient was near-diploid, in contrast with testicular germ cell tumors, which as a rule are near-triploid or near-tetraploid.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Chromosome Aberrations*
Chromosome Banding
Chromosomes, Human, Pair 12*
Dysgerminoma / genetics*
Dysgerminoma / pathology
Humans
Karyotyping
Male
Mediastinal Neoplasms / genetics*
Mediastinal Neoplasms / pathology