Retromer Sets a Trap for Endosomal Cargo Sorting

Ludger Johannes; Christian Wunder

doi:10.1016/j.cell.2016.11.026

Retromer Sets a Trap for Endosomal Cargo Sorting

Cell. 2016 Dec 1;167(6):1452-1454. doi: 10.1016/j.cell.2016.11.026.

Authors

Ludger Johannes¹, Christian Wunder²

Affiliations

¹ Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery unit, INSERM U 1143, CNRS UMR 3666, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Electronic address: [email protected].
² Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery unit, INSERM U 1143, CNRS UMR 3666, 26 rue d'Ulm, 75248 Paris Cedex 05, France.

PMID: 27912055
DOI: 10.1016/j.cell.2016.11.026

Abstract

Membrane trafficking from endosomes to the trans-Golgi network or the plasma membrane is driven by the retromer complex. Through structural analysis of the cargo-bound complex, Lucas et al. describe a mechanism by which endosomal membrane recruitment and cargo recognition are integrated through cooperative interactions between retromer subunits.

Publication types

Comment

MeSH terms

Cell Membrane / metabolism
Endosomes / metabolism*
Humans
Intracellular Membranes / metabolism
Protein Transport
Vesicular Transport Proteins / chemistry
trans-Golgi Network / metabolism*

Substances

Vesicular Transport Proteins