Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny

Purushothama Rao Tata; Jayaraj Rajagopal

doi:10.1016/j.stem.2016.11.009

Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny

Cell Stem Cell. 2016 Dec 1;19(6):686-689. doi: 10.1016/j.stem.2016.11.009.

Authors

Purushothama Rao Tata¹, Jayaraj Rajagopal²

Affiliations

¹ Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
² Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address: [email protected].

Abstract

Feedback signals from daughter cells to stem cells are well studied and known to provide important feedback cues. Emerging evidence shows that stem cells also send feedforward signals to their progeny. Complex circuits involving both negative and positive feedback and feedforward signals likely contribute to robust tissue maintenance and regeneration.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Autocrine Communication
Cell Lineage
Feedback, Physiological
Humans
Models, Biological
Signal Transduction*
Stem Cells / cytology*
Stem Cells / metabolism*

Abstract

Publication types

MeSH terms

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