From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

Cancer Metastasis Rev. 2016 Dec;35(4):655-667. doi: 10.1007/s10555-016-9650-0.

Abstract

The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment. Here, we address the contribution of ECM mechanics to breast cancer progression, metastasis, and treatment resistance and discuss potential therapeutic strategies targeting the ECM.

Keywords: Breast cancer; Desmoplasia; Extracellular matrix (ECM); Mechanosignaling; Metastasis; Treatment resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Breast Neoplasms / pathology*
  • Cell Transformation, Neoplastic / pathology*
  • Extracellular Matrix / pathology*
  • Humans
  • Mammary Neoplasms, Experimental / pathology
  • Neoplasm Metastasis