Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

Rev Bras Reumatol Engl Ed. 2016 Nov-Dec;56(6):515-520. doi: 10.1016/j.rbre.2016.07.013. Epub 2016 Oct 25.
[Article in English, Portuguese]

Abstract

We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.

Keywords: Fc gamma receptor IIIa; Gene polymorphism; Immunogenetics; Imunogenética; Lúpus eritematoso sistêmico; Polimorfismo de nucleotídeo único; Polimorfismo genético; Receptor Fc gama IIIa; Single nucleotide polymorphism; Systemic lupus erythematosus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Brazil
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Lupus Erythematosus, Systemic / immunology
  • Polymorphism, Genetic*
  • Receptors, IgG / genetics*

Substances

  • FCGR3A protein, human
  • Receptors, IgG