Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-naïve chronic lymphocytic leukemia

Haematologica. 2017 Apr;102(4):e144-e147. doi: 10.3324/haematol.2016.154450. Epub 2016 Dec 7.

Authors

Chiara Cavallini¹, Carlo Visco², Santosh Putta³, Davide Rossi⁴, Elda Mimiola⁵, Norman Purvis⁶, Ornella Lovato¹, Omar Perbellini², Erika Falisi², Monica Facco⁷, Livio Trentin⁷, Maria G Romanelli⁸, Gianpietro Semenzato⁷, Achille Ambrosetti⁵, Gianluca Gaidano⁹, Giovanni Pizzolo⁵, Alessandra Cesano¹⁰, Maria T Scupoli^{11

5}

Affiliations

¹ Research Center LURM, University of Verona, Italy.
² Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
³ Qognit Inc., Foster City, CA, USA.
⁴ Hematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Switzerland.
⁵ Department of Medicine, Section of Hematology, University of Verona, Italy.
⁶ Pierian Biosciences, Franklin, TN, USA.
⁷ Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.
⁸ Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Italy.
⁹ Department of Translational Medicine, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
¹⁰ NanoString, Inc, Seattle, WA, USA.
¹¹ Research Center LURM, University of Verona, Italy [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ADP-ribosyl Cyclase 1 / genetics
ADP-ribosyl Cyclase 1 / immunology
Disease Progression
Gene Expression Regulation, Leukemic*
Humans
Immunoglobulin Heavy Chains / genetics
Immunoglobulin Heavy Chains / metabolism
Immunoglobulin Variable Region / genetics
Immunoglobulin Variable Region / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics
Leukemia, Lymphocytic, Chronic, B-Cell / mortality
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Membrane Glycoproteins / genetics
Membrane Glycoproteins / immunology
Mitogen-Activated Protein Kinase 1 / genetics*
Mitogen-Activated Protein Kinase 1 / immunology
Mitogen-Activated Protein Kinase 3 / genetics*
Mitogen-Activated Protein Kinase 3 / immunology
Mutation
Phosphoproteins / genetics*
Phosphoproteins / immunology
Phosphorylation
Prognosis
RNA Splicing Factors / genetics*
RNA Splicing Factors / immunology
Receptor, Notch1 / genetics
Receptor, Notch1 / immunology
Receptors, Antigen, B-Cell / genetics*
Receptors, Antigen, B-Cell / immunology
Signal Transduction
Survival Analysis
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / immunology

Substances

Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Membrane Glycoproteins
NOTCH1 protein, human
Phosphoproteins
RNA Splicing Factors
Receptor, Notch1
Receptors, Antigen, B-Cell
SF3B1 protein, human
TP53 protein, human
Tumor Suppressor Protein p53
MAPK1 protein, human
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
CD38 protein, human
ADP-ribosyl Cyclase 1