Complex Trait Analyses of the Collaborative Cross: Tools and Databases

Ramesh Ram; Grant Morahan

doi:10.1007/978-1-4939-6427-7_5

Complex Trait Analyses of the Collaborative Cross: Tools and Databases

Methods Mol Biol. 2017:1488:121-129. doi: 10.1007/978-1-4939-6427-7_5.

Authors

Ramesh Ram¹, Grant Morahan²

Affiliations

¹ Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia.
² Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia. [email protected].

PMID: 27933522
DOI: 10.1007/978-1-4939-6427-7_5

Abstract

The Collaborative cross (CC) is a powerful mouse resource for investigating complex genetic traits. Here we discuss various tools and techniques for gene mapping and identification using the CC. The data analyses procedures are illustrated with examples.

Keywords: Analysis tools in systems genetics; Collaborative Cross; Haplotype analysis; Imputation; Mixed model; Quantitative trait loci (QTL) mapping methods; Whole-genome association.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping / methods
Computational Biology / methods
Crosses, Genetic*
Data Mining
Databases, Nucleic Acid*
Genetics, Population / methods
Genome
Genome-Wide Association Study
Genomics / methods
Genotype
Haplotypes
Mice
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci*
Quantitative Trait, Heritable*
Software*
User-Computer Interface